Masters and Johnson were also referenced in a Italian comedy directed by Bruno Corbucci, Il trafficone. No coaching or suggestions were made by the research team. This program reported a Backstage at fashion shows and at photo shoots, models are often expected to change in full view of photographers, stylists, assistants, and anyone else who may happen to be present. Few models told their agencies about it, perhaps because of the fact that of the models who did, two-thirds found that their agents didn't see the problem. Prior to , when they described their treatment program to the world for the first time, sexual dysfunctions such as premature ejaculation , impotence , vaginismus , and female frigidity had been generally treated by long-term multi-year psychotherapy or psychoanalysis with very low rates of success. Pfeiffer and colleagues published a study in the Journal of Virology last month January 18 , in which they showed that a specific virus replicated better in male mice than in females. But these trisomic female mice showed the most serious changes in their cerebellums. Usually, the discussion consisted of just a question or a suggestion, but often it was limited to nonverbal communicative expressions such as eye contact or hand movement, any of which usually proved sufficient to establish the protocol of partner interaction. The assumption of control was established without verbal communication and frequently with no obvious nonverbal direction, although on one occasion discussion as to procedural strategy continued even as the couple was interacting physically. This can contribute to differences in symptoms and potentially make it more difficult to detect heart disease in women. Despite the fact that the modeling labor force skews so young, the most models under the age of 18 are not supervised by a parent or guardian while on the job. Models report that drug use in the workplace is rampant. Thomas Maier stated "that Virginia Johnson had serious reservations about Masters' conversion theory, and she suspected that, at worst, the results of the study may have been fabricated by William Masters". Hite's work, however, has been challenged for methodological defects. Examining both male and female model organisms is worth the extra effort and added costs, most experts maintain, but whether the results translate to human studies is less clear.